Search hotels in Santa Cruz Region, Bolivia

Enter your dates and choose from 858 hotels and other places to stay

Check out these popular cities in Santa Cruz Region

Stay in Santa Cruz Region's best hotels!

Show hotels on map

Filter by:

Star rating
Review score

Cosmopolitano Hotel Boutique

Hotel in Santa Cruz de la Sierra

Offering an outdoor pool, Cosmopolitano Hotel Boutique is located in the historical centre of Santa Cruz de la Sierra. Guests can enjoy the on-site bar.

I
Irina
From
Romania
The room was very comfortable and estwtically pleasing and also the staff was really helpful and always available. The airport transfer they facilitated was great, the driver very helpful, shared a lot of information, and answered all our questions.
Scored out of 10, guest rating 9.1
Superb - What previous guests thought, 1,106 reviews
Price from
US$84.23
1 night, 2 adults
Check availability

TRYP by Wyndham Santa Cruz

Hotel in Santa Cruz de la Sierra

Situated in Santa Cruz de la Sierra, 1.6 km from Gabriel Rene Moreno Autonomous University, TRYP by Wyndham Santa Cruz features accommodation with an outdoor swimming pool, free private parking, a...

L
Leo MFM
From
Brazil
Very comfortable hotel. Bed is soft, room is spacious, shower is perfect, the pool is nice, staff are helpful and location is great.
Scored out of 10, guest rating 9.0
Superb - What previous guests thought, 590 reviews
Price from
US$79
1 night, 2 adults
Check availability

YVY CASA HOTEL

Hotel in Samaipata

Located in Samaipata, 10 km from Samaipata Fort, YVY CASA HOTEL provides accommodation with a garden, free private parking and a terrace.

J
Joanna
From
Germany
I can't praise this hotel enough! Really friendly staff. The rooms are all individually designed and even if you can't relate to Feng Shui, the hotel exudes peace and tranquillity. The perfect pace to chill after exploring Amboro National Park. The centre of Samaipata is just a 10-minute walk away. They served the best breakfast we had in 3 weeks in Bolivia with freshly baked flatbread and pancakes, home-made jams and marinated vegetables. I definitely recommend staying here if you're in Samaipata.
Scored out of 10, guest rating 9.3
Superb - What previous guests thought, 449 reviews
Price from
US$55
1 night, 2 adults
Check availability

El Pueblito Hotel Boutique

Hotel in Samaipata

Situated in Samaipata, 11 km from Samaipata Fort, El Pueblito Hotel Boutique features accommodation with an outdoor swimming pool, free private parking, a garden and a shared lounge.

E
Erna
From
Switzerland
Everything. Beautiful rooms, very friendly people and nice surrounding.
Scored out of 10, guest rating 9.5
Exceptional - What previous guests thought, 189 reviews
Price from
US$93.45
1 night, 2 adults
Check availability

Hotel Cortez

Hotel in Santa Cruz de la Sierra

Boasting an outdoor swimming pool, gym and spa facilities, Hotel Cortez has chic and spacious rooms in Santa Cruz de la Sierra. Free WiFi access is available.

G
Graham
From
United Kingdom
Recently fully refurbished, the high standards and professionalism of the staff were only matched by their friendliness and helpfulness. Superb location, restaurants nearby. We stayed 14 nights, a fantastic 5 star experience in the middle of Santa Cruz.
Scored out of 10, guest rating 9.2
Superb - What previous guests thought, 219 reviews
Price from
US$148.50
1 night, 2 adults
Check availability

Hotel By Armonía Santa Cruz

Hotel in Santa Cruz de la Sierra

Set in Santa Cruz de la Sierra, 1.6 km from Güembé Biocentre and Guazú Ivaga Park, Hotel By Armonía Santa Cruz offers accommodation with an outdoor swimming pool, free private parking, a garden and a...

A
Aleksandr
From
Russia
Very friendly and caring staff, absolutely everyone were very nice and friendly with us. We enjoyed the breakfast - we got it served, very fast, - it was very ample and nutritious; the swimming pool was warm, clean and deep enough; the interior as well as the exterior were fantastic, we enjoyed the garden and the location too - it was very quiet. Good wifi, excellent spacious shower room.
Scored out of 10, guest rating 9.3
Superb - What previous guests thought, 92 reviews
Price from
US$65.03
1 night, 2 adults
Check availability

La Vida es Bella

Hotel in Samaipata

Set in Samaipata, 9 km from Samaipata Fort, La Vida es Bella offers accommodation with a garden, free private parking, a shared lounge and a terrace.

N
Niclas
From
Austria
The accommodation was wonderful – from the room to the garden, everything was just perfect. The place and the hosts were exceptional. It was extraordinarily clean, and the room was full of thoughtful details. The balcony was beautiful, and the location couldn't have been better. Simply a place to feel at home and completely relaxed. On top of that, we had an extremely delicious breakfast.
Scored out of 10, guest rating 9.0
Superb - What previous guests thought, 83 reviews
Price from
US$65
1 night, 2 adults
Check availability

Lido Hotel

Hotel in Santa Cruz de la Sierra

Lido Hotel features accommodation in Santa Cruz de la Sierra near Metropolitan Cathedral and Gabriel Rene Moreno Autonomous University.

O
Ole
From
Denmark
Nice hotel a few blocks from the central square. The area is safe
Scored out of 10, guest rating 8.6
Fabulous - What previous guests thought, 109 reviews
Price from
US$44.06
1 night, 2 adults
Check availability

Novotel Santa Cruz De La Sierra

Hotel in Santa Cruz de la Sierra

Set in Santa Cruz de la Sierra, 3.5 km from Gabriel Rene Moreno Autonomous University, Novotel Santa Cruz De La Sierra offers accommodation with an outdoor swimming pool, free private parking, a...

J
Jose Miguel
From
Bolivia
Comfortable beds. Good breakfast.
Scored out of 10, guest rating 8.5
Very good - What previous guests thought, 187 reviews
Price from
US$94.50
1 night, 2 adults
Check availability

Chairu Eco Hotel

Hotel in Santa Cruz de la Sierra

Chairu Eco Hotel features a shared lounge, terrace, a restaurant and bar in Santa Cruz de la Sierra.

K
Kavya
From
United States
Tranquil and spotless, extremely comfortable beds and spacious rooms. Breakfast was fresh and tasty, and the staff were extremely kind and accommodating!
Scored out of 10, guest rating 8.9
Fabulous - What previous guests thought, 798 reviews
Price from
US$75
1 night, 2 adults
Check availability
See all 858 hotels in Santa Cruz Region

Most booked hotels in Santa Cruz Region in the past month

See all

Santa Cruz Region's best hotels with breakfast

  • Scored out of 10, guest rating 8.9
    Fabulous - What previous guests thought, 272 reviews

    Set in Santa Cruz de la Sierra, 1.3 km from Arenal Park, ibis Santa Cruz de la Sierra offers accommodation with a shared lounge, free private parking, a restaurant and a bar.

    From US$72 per night
  • Scored out of 10, guest rating 8.5
    Very good - What previous guests thought, 187 reviews

    Set in Santa Cruz de la Sierra, 3.5 km from Gabriel Rene Moreno Autonomous University, Novotel Santa Cruz De La Sierra offers accommodation with an outdoor swimming pool, free private parking, a...

    From US$105 per night
  • Scored out of 10, guest rating 8.9
    Fabulous - What previous guests thought, 798 reviews

    Chairu Eco Hotel features a shared lounge, terrace, a restaurant and bar in Santa Cruz de la Sierra.

    From US$80 per night
  • Scored out of 10, guest rating 8.9
    Fabulous - What previous guests thought, 278 reviews

    Situated in Santa Cruz de la Sierra, 4.5 km from Gabriel Rene Moreno Autonomous University, Swissotel Santa Cruz de La Sierra features accommodation with an outdoor swimming pool, free private parking...

    From US$148 per night
  • Scored out of 10, guest rating 8.0
    Very good - What previous guests thought, 293 reviews

    Located in Santa Cruz de la Sierra, 2.2 km from Gabriel Rene Moreno Autonomous University, Delfines Collection Hotel by Mercure provides accommodation with an outdoor swimming pool, free private...

    From US$62.57 per night
  • Scored out of 10, guest rating 8.7
    Fabulous - What previous guests thought, 351 reviews

    Located in Santa Cruz de la Sierra, 2.1 km from Gabriel Rene Moreno Autonomous University, Hampton by Hilton Santa Cruz provides accommodation with a fitness centre, free private parking, a garden and...

    From US$103.84 per night
  • Scored out of 10, guest rating 8.6
    Fabulous - What previous guests thought, 162 reviews

    Featuring 5-star accommodation, Mai Suites Apart Hotel is situated in Santa Cruz de la Sierra, 2 km from Gabriel Rene Moreno Autonomous University and 4.2 km from Arenal Park.

    From US$85 per night
  • Scored out of 10, guest rating 8.1
    Very good - What previous guests thought, 390 reviews

    Located in the commercial district of Equipetrol, this property offers accommodations with free WiFi access in Santa Cruz de la Sierra.

    From US$66.89 per night

Budget hotels in Santa Cruz Region

  • Scored out of 10, guest rating 8.3
    Very good - What previous guests thought, 644 reviews

    Situated in Santa Cruz de la Sierra, 400 metres from Güembé Biocentre and Guazú Ivaga Park, HOTEL OSHO features accommodation with an outdoor swimming pool, free private parking, a fitness centre and...

    From US$49.50 per night
  • Scored out of 10, guest rating 8.0
    Very good - What previous guests thought, 392 reviews

    Set in Santa Cruz de la Sierra, within 1.9 km of Sacred Art Museum and 2.6 km of Metropolitan Cathedral, Prince Hotel offers accommodation with a garden and as well as free private parking for guests...

    From US$56 per night
  • Scored out of 10, guest rating 8.5
    Very good - What previous guests thought, 235 reviews

    Situated in Santa Cruz de la Sierra, 1.9 km from Gabriel Rene Moreno Autonomous University, Hotel Sirari By Regina features accommodation with an outdoor swimming pool, free private parking, a fitness...

    From US$95 per night
  • Scored out of 10, guest rating 8.3
    Very good - What previous guests thought, 316 reviews

    The LP Santa Cruz Hotel is a 3-star hotel located few metres from Blacutt Square in central Santa Cruz. It offers rooms with cable TV, a minibar and free Wi-Fi.

    From US$61.83 per night
  • Scored out of 10, guest rating 8.7
    Fabulous - What previous guests thought, 10 reviews

    Set in Santa Cruz de la Sierra, 500 metres from Sacred Art Museum, Santa Cruz Home features a terrace and views of the city.

    From US$24 per night
  • Scored out of 10, guest rating 8.4
    Very good - What previous guests thought, 14 reviews

    Hotel Boutique Plaza24 has a shared lounge, terrace, a restaurant and bar in Santa Cruz de la Sierra. This 4-star hotel offers a shared kitchen and room service.

    From US$60 per night
  • Scored out of 10, guest rating 8.8
    Fabulous - What previous guests thought, 87 reviews

    Situated in Santa Cruz de la Sierra, 3.1 km from Güembé Biocentre and Guazú Ivaga Park, Hotel Maywa features accommodation with a fitness centre, free private parking, a shared lounge and a terrace.

    From US$48.45 per night
  • Scored out of 10, guest rating 7.8
    Good - What previous guests thought, 1,111 reviews

    Featuring an outdoor pool, La Siesta Hotel offers accommodations in Santa Cruz de la Sierra. Free WiFi access is available.

    From US$83.62 per night

Hotels in Santa Cruz Region that you can book without a credit card

  • Scored out of 10, guest rating 8.4
    Very good - What previous guests thought, 17 reviews

    Boasting a terrace and barbecue facilities, LA CASONA Hotel Boutique is set in Camiri.

    From US$40 per night
  • Scored out of 10, guest rating 7.2
    Good - What previous guests thought, 138 reviews

    Situated in Santa Cruz de la Sierra, 800 metres from Sacred Art Museum, Ex Hotel Asturias Centrico features accommodation with an outdoor swimming pool, free private parking, a garden and a terrace.

    From US$26.68 per night
  • Scored out of 10, guest rating 7.2
    Good - What previous guests thought, 280 reviews

    Residencial IKANDIRE ll is located in Santa Cruz de la Sierra, 1.4 km from Metropolitan Cathedral and 1.3 km from Güembé Biocentre and Guazú Ivaga Park.

    From US$14.50 per night
  • Scored out of 10, guest rating 7.4
    Good - What previous guests thought, 178 reviews

    Featuring a swimming pool, a fitness centre and a restaurant, Hotel Arenal offers rooms with free Wi-Fi and flat-screen TVs in Santa Cruz de la Sierra. Free parking is provided.

    From US$69.90 per night
  • Scored out of 10, guest rating 6.5
    Pleasant - What previous guests thought, 6 reviews

    Mansión By Hotel Casablanca is a 2-star property set in Samaipata. The property is non-smoking and is situated 9.2 km from Samaipata Fort. All rooms in the hotel are fitted with a flat-screen TV.

    From US$42.90 per night

  • Hotel Casa Blanca is a 5-star property set in La Playa Bejarano. The units come with air conditioning, a flat-screen TV with satellite channels, a fridge, a coffee machine, a shower, free toiletries...

    From US$33 per night
  • Scored out of 10, guest rating 7.7
    Good - What previous guests thought, 14 reviews

    Featuring a terrace, Hotel el Marqués is set in Vallegrande. Among the facilities of this property are a restaurant, room service and a 24-hour front desk, along with free WiFi throughout the property...

    From US$38.50 per night
  • Scored out of 10, guest rating 8.0
    Very good - What previous guests thought, 2 reviews

    Hotel La Casona de Don Pepe in Roboré has 2-star accommodation with an outdoor swimming pool, a garden and a terrace.

    From US$58 per night

FAQs about hotels in Santa Cruz Region

See reviews by guests who stayed at hotels in Santa Cruz Region

See all

  • La Vida es Bella

    Samaipata
    From US$65 per night
    Scored out of 10, guest rating 9.0
    Superb - What previous guests thought, 83 reviews
    The accommodation was wonderful – from the room to the garden, everything was just perfect. The place and the hosts were exceptional. It was extraordinarily clean, and the room was full of thoughtful details. The balcony was beautiful, and the location couldn't have been better. Simply a place to feel at home and completely relaxed. On top of that, we had an extremely delicious breakfast.
    Guest review by
    Niclas
    Austria

  • Hotel LP Santa Cruz Centro

    Santa Cruz de la Sierra
    From US$61.83 per night
    Scored out of 10, guest rating 8.3
    Very good - What previous guests thought, 316 reviews
    Breakfast was the only thing I did not like at this hotel. I did not find the food very appealing. The cakes were not tasty and did not have enough fruit. The breakfast was very predictable. The location was great. It was right where we wanted to be, near the Stadium.
    Guest review by
    Edson L Sanches
    United States

  • Prince Hotel

    Santa Cruz de la Sierra
    From US$56 per night
    Scored out of 10, guest rating 8.0
    Very good - What previous guests thought, 392 reviews
    I liked all about this place. Very clean, quiet, modern, with all facilities! All I needed and expected to have, I had it at the reach of my hand. People were very nice and helped me with all questions I could have. I'd recommend this place to everyone!
    Guest review by
    Jacek
    Canada

  • Hotel Cortez

    Santa Cruz de la Sierra
    From US$153 per night
    Scored out of 10, guest rating 9.2
    Superb - What previous guests thought, 219 reviews
    Recently fully refurbished, the high standards and professionalism of the staff were only matched by their friendliness and helpfulness. Superb location, restaurants nearby. We stayed 14 nights, a fantastic 5 star experience in the middle of Santa Cruz.
    Guest review by
    Graham
    United Kingdom

  • Sun Hotel

    Santa Cruz de la Sierra
    From US$120 per night
    Scored out of 10, guest rating 7.6
    Good - What previous guests thought, 539 reviews
    Free airport shuttle. They were willing to wait for me at the airport while I had a Bolivian SIMM card put in my phone and had the phone registered.
    Guest review by
    Howard
    Canada

  • La Siesta Hotel

    Santa Cruz de la Sierra
    From US$83.62 per night
    Scored out of 10, guest rating 7.8
    Good - What previous guests thought, 1,111 reviews
    This place is beautiful. The grounds are lovely, the buildings are love, the staff are lovely, the rooms are super lovely and the pool is excellent
    Guest review by
    Sarah
    Australia

  • El Pueblito Hotel Boutique

    Samaipata
    From US$105 per night
    Scored out of 10, guest rating 9.5
    Exceptional - What previous guests thought, 189 reviews
    Everything. Beautiful rooms, very friendly people and nice surrounding.
    Guest review by
    Erna
    Switzerland

  • Hotel Arenal

    Santa Cruz de la Sierra
    From US$69.90 per night
    Scored out of 10, guest rating 7.4
    Good - What previous guests thought, 178 reviews
    Good value, comfortable, close to the plaza and helpful staff.
    Guest review by
    Michael
    Peru

  • LP Equipetrol

    Santa Cruz de la Sierra
    From US$66.89 per night
    Scored out of 10, guest rating 8.1
    Very good - What previous guests thought, 390 reviews
    Location and faculties were fabulous and quite a trendy Hotel
    Guest review by
    stuart
    United Kingdom

  • Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

    Santa Cruz de la Sierra
    From US$125.10 per night
    Scored out of 10, guest rating 8.8
    Fabulous - What previous guests thought, 486 reviews
    Great stay. Outstanding service
    Guest review by
    Munoz
    Panama

Planning a trip? Get inspired by reviews of cities in Santa Cruz Region

  • 6.0

    It's a city with not much to offer.

    It's a city with not much to offer. You're better off in La Paz, where the views are nicer, the scenery is just better. But you're really much better off in the more rural places, in the mountains, by the lakes and away from the cities.
    Guest review by
    Ognyan
    United Kingdom
  • 8.0

    Santa Cruz de la Sierra is an interesting city with a busy...

    Santa Cruz de la Sierra is an interesting city with a busy and parcely old part downtown. You find museums, the main plaza with the cathedral, shops for everyone, big restaurants and small places who sell delicious local food. Also thera are some modern shopping malls as also black markets where you find everything you might need for living. Cultural events are offered and some really nice places with abundant semi-tropical vegetation as well as places with a lake to swim and hotels. You can take a taxi or go by bus to almost every place you like, in general it is very safe, only in the outskirts you should be more careful and maybe not go there at nigt. Always take your purse with important things in front of you - just in case! I certainly recommend Santa Cruz for a visit! A little bit outside there are the sanddunes and the botanical garden and other places like the Chiquitania, also very worth visiting!
    Guest review by
    Cornelia
    Germany
  • 8.0

    Friendly people (is famous for its hospitality).

    Friendly people (is famous for its hospitality). Is the most productive area of the country, you can find everything you expect of a big city. I like my staying and I will be back with more time and better organized agenda. Given the size of the city and the weather (mostly humid and hot) a car is necessary to visit properly Santa Cruz.
    Guest review by
    Flavio David Y.
    Bolivia

Research, refine and make plans for your whole trip

Hotels near Viru Viru International Airport

Find hotels conveniently close to the area's most popular airport – perfect for a late arrival or early departure.

Car hire near Viru Viru International Airport

Pick up your rental car as soon as you touch down.

Hotels on Isla del Sol Island

Discover another popular destination within Bolivia.

Hotels in Uyuni Salt Flat

Discover another popular destination within Bolivia.

Hotels in Santa Cruz de la Sierra

A popular choice with guests visiting Santa Cruz Region.

Cheap holidays in Santa Cruz de la Sierra

Book the best flights, stays and more – all in one place

Flights from London to Santa Cruz de la Sierra

Need to book flights for your trip? Find and compare prices for this and other popular routes right here on Booking.com.

Hotels in Bolivia

Set off to explore the whole country.

Flights to Santa Cruz Region

Reaching Santa Cruz Region just got easier!